2014 Fiscal Year Final Research Report
Design and synthesis of kainoid-type molecular probes for elucidation of the mechanism of allodynia induction
Project/Area Number |
24310154
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Living organism molecular science
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Research Institution | Gifu University |
Principal Investigator |
FURUTA Kyoji 岐阜大学, 医学(系)研究科(研究院), 准教授 (40173538)
|
Co-Investigator(Renkei-kenkyūsha) |
MINAMI Toshiaki 大阪医科大学, 医学研究科, 教授 (00257841)
DOI Hisashi 理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー (00421818)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | アロディニア / 神経障害性疼痛 / アクロメリン酸 / カイノイド / 分子プローブ / グルタミン酸受容体 |
Outline of Final Research Achievements |
Several kainoid-type analogs were designed and synthesized for the purpose of identifying a novel receptor involved in the induction and maintenance of allodynia, a major symptom of neuropathic pain. Efficient synthetic methods to selectively modify the individual substituents attached to the pyrrolidine-ring skeleton of kainoids were established, making it possible to easily prepare kainoid analogs with a variety of substituents. Evaluation of the synthetic kainoids for allodynia-inducing/suppressing activity and binding affinity for glutamate receptors specified some promising analogs as biochemical tools. The existence of a novel activation mechanism of kainate receptor was also suggested.
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Free Research Field |
生物有機化学
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