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2014 Fiscal Year Final Research Report

Discovery of coumarin prenyltransferase family and the regulation of catalytic function

Research Project

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Project/Area Number 24310156
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Living organism molecular science
Research InstitutionKyoto University

Principal Investigator

YAZAKI Kazufumi  京都大学, 生存圏研究所, 教授 (00191099)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Akifumi  京都大学, 生存圏研究所, 助教 (20598601)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywordsプレニル基転移酵素 / クマリン / ジメチルアリルジリン酸 / ゲラニルジリン酸 / 膜結合性酵素 / 色素体局在
Outline of Final Research Achievements

Prenylated coumarins widely occur in Apiaceae and Rutaceae. They show toxicity to herbivores and pathogens serving as protectants for plants that produce those metabolites, while those coumarin compounds show a variety of biological activities to humans, as well. Prenyltransferase, a key enzyme in the biosynthesis, has been first identified at the gene level from parsley (Apiaceae) and lemon (Rutaceae).
Prenyltransferase family for coumarins show high hydrophobicity via typically nine transmembrane alpha-helices, and they show strict specificity to both prenyl donor and acceptor substrates. For the catalytic function, Mg2+ is required and the subcellular localization of these membrane proteins is demonstrated to be plastids in plant cells.

Free Research Field

植物生化学

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Published: 2016-06-03  

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