2014 Fiscal Year Final Research Report
Development of novel drug for bone-related diseases using Pirin inhibitors
| Project/Area Number |
24310167
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Keio University |
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Principal Investigator |
SIMIZU Siro 慶應義塾大学, 理工学部, 准教授 (30312268)
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| Co-Investigator(Renkei-kenkyūsha) |
UMEZAWA Kazuo 愛知医科大学, 医学部, 教授 (70114402)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 骨関連疾患 / Pirin / 破骨細胞 |
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| Outline of Final Research Achievements |
The number of bone-related disease patients is increasing in Japan. At present, bisphosphonates are widely used for these diseases, but their severe side effects are impossible to ignore.
We focused on TPh A, a Pirin inhibitor, as a novel drug for such diseases. We assayed many derivatives of TPh A and found that 2 compounds inhibited RANKL-induced osteoclastgenesis on Pirin-independent manner without cytotoxicity. These compounds did not suppress phosphorylation of MAPKs, although its inhibited expression of c-Fos and DC-STAMP. Therefore, it is suggested that the compounds we found might be candidates for drugs of bone-related diseases.
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| Free Research Field |
ケミカルバイオロジー
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