2014 Fiscal Year Final Research Report
Natural Product Synthesis by Utilizing Compact and Multifunctional Properties of Cyano Group
| Project/Area Number |
24350018
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
TANINO Keiji 北海道大学, 理学研究院, 教授 (40217146)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 有機化学 / 天然物化学 / 全合成 / ニトリル |
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| Outline of Final Research Achievements |
The synthetic studies on Tubiferal A, Azadirachtin, and Phorbol were carried out on the basis of new reactions utilizing alkanenitriles. The unique properties of a cyano group, which is sterically compact and linear in shape, were found to be advantageous for forming carbocyclic compounds possessing hindered carbon-carbon bonds. For example, construction of the 5-7 bicyclic skeleton of Phorbol was achieved by the divinylcyclopropane rearrangement reaction of a cyanocyclopropane derivative.
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| Free Research Field |
有機合成化学
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