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2014 Fiscal Year Final Research Report

Asymmetric Cyanation and Hydrogenation Catalyzed by Ruthenium Complexes

Research Project

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Project/Area Number 24350042
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Synthetic chemistry
Research InstitutionHokkaido University

Principal Investigator

OHKUMA Takeshi  北海道大学, 工学(系)研究科(研究院), 教授 (50201968)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords触媒的不斉合成 / 不斉シアノ化反応 / 不斉水素化反応 / ケトン / イミン / シアン化化合物 / アルコール / アミン
Outline of Final Research Achievements

Chiral Ru-Li combined systems developed by our research group efficiently catalyzed 1) hydrocyanation of aldehydes and N-protected aldimines, 2) cyanosilylation of simple and α-alkoxy ketones, and 3) conjugate hydrocyanation of α,β-unsaturated ketones and N-acylpyrroles. The substrate-to-catalyst molar ratio of 10,000 and enantioselectivity of 99% were achieved in the best cases.
The novel chiral Ru complexes achieved 1) very rapid and highly enantioselective hydrogenation of ketones, 2) asymmetric hydrogenation of N-arylimines, quinoxalines, and benzoxazines. The rate (turnover frequency) of the hydrogenation of ketones reached about 35,000 per minute with grater than 99% enantioselectivity. The turnover number of 18,000 and enantioselectivity of 99% in the reaction of N-arylimines were obtained in the best cases.

Free Research Field

有機合成化学

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Published: 2016-06-03  

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