2015 Fiscal Year Final Research Report
Investigation on biological activity of cyclic dinucleotides and elucidation of mechanism how the activity is expressed, directing toward invention of new immunostimulants
| Project/Area Number |
24350087
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Aichi Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Nishimura Akiko 愛知工業大学, 工学部, 准教授 (90609322)
Ohta Michio 椙山女学園大学, 看護学部, 教授 (20111841)
Hyodo Mamoru 愛知工業大学, 工学部, 講師 (30548186)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 環状ジヌクレオチド / c-di-GMP / 2',3'-cGAMP / 免疫活性 / がん細胞増殖抑制 / STING |
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| Outline of Final Research Achievements |
We analyzed the physiological activity of bis (3'-5') cyclic diguanylic acid（c-di-GMP）and other cyclic dinucleotides having similar structure. Our results demonstrated the important bioactivity of c-di-GMP to inhibit the metastases of breast cancer and to attenuate experimental autoimmune encephalitis. During the immune response against cytosolic DNA, cyclic-GMP-AMP (cGAMP) was proposed to bind to an immunoreceptor called STING. Here we demonstrated that non-canonical cyclic dinucleotides 2',3'-cGAMP, which contains a single 2’-5’ phosphodiester bond, activated STING and induced the production of type I interferons.
These are valuable findings for the development of the research and our final goal ”invention of useful immunostimulator”.
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| Free Research Field |
核酸有機化学
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