Fundamental study on the luminescent properties of the inorganic hollow phosphors to contribute to the drug delivery system

2014 Fiscal Year Final Research Report

• Project/Area Number: 24350098
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Functional materials/Devices
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: JIN Tetsuro 独立行政法人産業技術総合研究所, ユビキタスエネルギー研究部門, 主任研究員 (30357248)
• Co-Investigator(Kenkyū-buntansha): OCHIISHI Tomoyo 産業総合技術研究所, バイオメディカル研究部門, 主任研究員 (30356729) ; YAZAWA Tetsuo 兵庫県立大学, 大学院工学研究科, 教授 (50347522) ; DAIKO Yusuke 名古屋工業大学, 大学院工学研究科, 助教 (70514404)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 希土類蛍光体 / ドラッグデリバリーシステム / 分相 / ガラス / 表面改質 / 生体親和性

Outline of Final Research Achievements

Neutron capture therapy (NCT) is one of available ways for intractable cancers in human body. BNCT is in practical use, in addition, gadolinium neutron capture therapy (GdNCT) is also useful because Gd ion has a toxicity against human calls by gamma-ray generation under irradiation thermal neutrons. Using a lanthanide phosphor including Gd synthesized by our technique, the phosphors are able to form unique shapes such as hollow sphere, and the phosphor showing a good emission can be used as a new type drug delivery system (DDS) possessing several functions such as gamma-ray generation under irradiation of thermal neutron, drug delivery and lavel of the tumor cells in one material. In this study, the preparation of hollow sphere lanthanide phosphor was performed using polymer beads as a template by hydrothermal treatment. And then the tumor cell killing effect of this material against cultured the cancer cell after irradiation of thermal neutron and incubation was investigated.

Free Research Field

無機材料工学