Study on the generation, control and destruction of functional microbubbles.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24360067
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Fluid engineering
• Research Institution: The University of Tokyo
• Principal Investigator: TAKAGI SHU 東京大学, 工学(系)研究科(研究院), 教授 (30272371)
• Co-Investigator(Kenkyū-buntansha): SUGIYAMA Kazuyasu 大阪大学, 大学院基礎工学研究科, 教授 (50466786) ; ICHIYANAGI Mitsuhisa 上智大学, 理工学部, 准教授 (00584252)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 混相流 / マイクロ流体 / 気泡力学 / 医療応用 / 超音波 / DDS

Outline of Final Research Achievements

To get a fundamental knowledge on the microbubble drag delivery system using ultrasound-contrast-agent, two kinds of experiments were conducted. One is the surface modification of microbubbles for selective adhesion to the target. The other is manipulation of microbubbles using ultrasound field. In this study, we succeeded to achieve the selective adhesion of microbubbles with the surface modification using biotin molecules, to the avidin-coated solid wall. We further developed the microbubble manipulation system using focused ultrasound and succeeded to manipulate them on arbitrary trajectories in 2-D plane. We also succeeded to trap the microbubble clusters under the presence of flows. These results give us the fundamental knowledge for the future possible applications.

Free Research Field

工学