Evaluation of cavitation from bubble mist and development to sonopolation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24360155
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Measurement engineering
• Research Institution: Gunma University
• Principal Investigator: YAMAKOSHI Yoshiki 群馬大学, 大学院理工学府, 教授 (10174640)
• Co-Investigator(Kenkyū-buntansha): SUNAGUCHI Naoki 群馬大学, 大学院理工学府, 助教 (60536481)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ドラッグデリバリシステム / 音響放射圧 / 気泡クラウド / 気泡ミスト / キャビテーション

Outline of Final Research Achievements

Ultrasonic wave assisted drug delivery system which uses micro bubbles of less than several microns in diameter including medicine is effective because sonopolation which makes small pores on the cell membrane can be applied for the injection of dug into the cell. Purpose of this research is that cavitation from bubble cloud is evaluated and a method in order to improve the efficiency of sonoporation is developed. By evaluation of bubble cloud dynamics under high intensity ultrasonic wave irradiation using optical observation by high speed camera, an optimum ultrasonic wave irradiation sequence for bubble cloud cavitation is proposed. In-situ observation of bubble cloud cavitation and ultrasonic wave field visualization method which are important tools in ultrasonic wave assisted drug delivery system are developed. These methods uses ultrasonic power Doppler imaging method to visualize the sound field and the bubble cloud cavitation.

Free Research Field

波動情報処理