Biodistribution and Luminecent Properties of Ceramic Nanoparticles for Biophotonics

2014 Fiscal Year Final Research Report

• Project/Area Number: 24360276
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Inorganic materials/Physical properties
• Research Institution: Tokyo University of Science
• Principal Investigator: SOGA Kohei 東京理科大学, 基礎工学部, 教授 (50272399)
• Co-Investigator(Kenkyū-buntansha): KISHIMOTO Hidehiro 琉球大学, 医学研究科, 教授 (80251213) ; HIYODO Hiroshi 東京理科大学, 基礎工学部, 助教 (30548863)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: バイオイメージング / 近赤外 / 蛍光 / 希土類 / セラミックス / ナノ粒子

Outline of Final Research Achievements

Ceramic nanoparticles with size control were surface-modified with biofunctional polymers. The suspension of the particles was injected through tail vain to be observed by OTN-NIR in vivo imaging system to trace the behavior of the nanoparticles in mice body. The particles with 60 nm size circulated in the blood vessel for at least 24 hrs while those with more than 100 nm were trapped by RES within 15 sec. In some case, they can circulate for the 15 min, though eventually after 1 hr, they are trapped by the RES. In this case, initially well modified the biofunctional polymers on the particle surface eventually detached to cause the agglomeration of the particles. The results suggest that the next step of the research to form firmer surface modification is important.

Free Research Field

材料工学