2014 Fiscal Year Final Research Report
Crystallographic study of multidrug efflux proteins coupled with outer membrane channel TolC
| Project/Area Number |
24370045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 異物排出トランスポーター / 立体構造 / 多剤耐性 |
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| Outline of Final Research Achievements |
Xenobiotic extruding pumps have recently been known to be widely distributed in living organisms from mammalian to bacteria as a host-defense mechanism in cellular level. These pumps confer multidrug resistance for cancer cells and pathogenic bacteria. We had reported the first inhibitor-bound structures of MexB which couples with TolC type outer membrane channel. Additionally, we succeeded in solving the crystal structure of new substrate binding MexB. These are result to lead to transporter-oriented structure based drug development.
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| Free Research Field |
構造生物学
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