Regulatory system of chromosomal stability by molecules including a novel molecule, CAMP

2014 Fiscal Year Final Research Report

• Project/Area Number: 24370078
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Tohoku University
• Principal Investigator: TANAKA Kozo 東北大学, 加齢医学研究所, 教授 (00304452)
• Co-Investigator(Renkei-kenkyūsha): ITOH Go 東北大学, 加齢医学研究所, 助教 (60607563) ; HIROTA Toru 公益財団法人がん研究会, がん研究所, 部長 (50421368) ; YASUI Akira 東北大学, 加齢医学研究所, 教授 (60191110) ; KANNO Shin-ichiro 東北大学, 加齢医学研究所, 講師 (10400417)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌 / 細胞・組織 / 染色体 / 細胞分裂

Outline of Final Research Achievements

We addressed the regulatory mechanism of chromosomal stability, and following findings were obtained. 1) A novel molecule CAMP functions as a complex with HP1, REV7, and POGZ. CAMP knockout mice die soon after birth. 2) A nuclear pore complex component Nup188 recruits NuMA to spindle poles for chromosome segregation. 3) A microtubule associated factor CLIP-170 regulates chromosome segregation through the mechanisms such as Plk1 recruitment to kinetochores. 4) Two motor molecules, Kid and CENP-E, function for chromosome alignment on the spindle.

Free Research Field

細胞生物学