2014 Fiscal Year Final Research Report
Molecular mechanisms of neuronal identity acquisition in olfactory sensory neurons
| Project/Area Number |
24370087
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | University of Fukui (2013-2014)
The University of Tokyo (2012) |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
NAKASHIMA Ai 福井大学, 医学部, 学術研究員 (60706331)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 神経科学 / 神経回路 / 嗅覚 / 発生 / 軸索ガイダンス / 感覚情報 / 脳科学 |
|---|
| Outline of Final Research Achievements |
In the mouse olfactory system, olfactory sensory neurons (OSNs) expressing the same olfactory receptor (OR) converge their axons to a specific set of glomeruli in the olfactory bulb. It has been demonstrated that ORs control transcriptional levels of axon guidance and sorting molecules to regulate axonal projection of OSNs. However, it remains unknown what is the signaling source for activating ORs. In the present study, we found that ligand-independent basal activities induced by expressed ORs play important roles in the targeting of OSN axons. This finding provides compelling evidence that the basal activity, which had been considered to be noise, is physiologically-important.
|
| Free Research Field |
神経科学
|
