2014 Fiscal Year Final Research Report
Regulatory network and chromatin dynamics of meiosis induction in the germline
| Project/Area Number |
24370089
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 減数分裂 / クロマチン / 生殖細胞 |
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| Outline of Final Research Achievements |
We established a culture system to induce meiotic transition (leptotene-zygotene stage of prophase I) of mitotically proliferating mouse germline stem cells in vitro. In this research project, we carried out multi-omics analyses and cell biological studies of the in vitro differentiation model of meiosis induction in germline stem cells. Integrated analyses of transcriptome and proteome regulation led to a comprehensive characterization of the key initial processes of chromatin remodeling in meiotic nuclei of mammalian germ cells.
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| Free Research Field |
発生生物学
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