2014 Fiscal Year Final Research Report
Mode of functions of plasmid as the modulator of host chromosomal functions
| Project/Area Number |
24380043
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
NOJIRI Hideaki 東京大学, 生物生産工学研究センター, 教授 (90272468)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | プラスミド / 染色体 / 遺伝子発現 / 転写制御 / 核様体 |
|---|
| Outline of Final Research Achievements |
To elucidate the modulation mechanism of host chromosomal functions by plasmid, the reduction of osmotic stress tolerance and the induction/reduction of the specific genes by plasmid carriage were investigated. In addition, mechanisms of dimerization/multimerization of plasmid-borne H-NS family proteins were investigated by protein-protein cross-linking assays and protein structure determined by X-ray crystallography.
|
| Free Research Field |
環境微生物学
|
