Construction of a biosynthetic logic toward a new era of natural product

2015 Fiscal Year Final Research Report

• Project/Area Number: 24380052
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied microbiology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Takahashi Shunji 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー (30311608)
• Co-Investigator(Kenkyū-buntansha): Okumura Hideo 公益財団法人 高輝度光科学研究センター, タンパク質結晶解析推進室, 研究員 (90377903)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 生合成 / スピロアセタール / アルキルマロニルCoA / リベロマイシン / 放線菌 / ポリケチド / CoAリガーゼ

Outline of Final Research Achievements

In a post genome era, it is important to reveal the function of unknown genes included in microbial secondary metabolite gene cluster. The findings can be utilized for the production of novel compounds. In this study, we focused on novel enzymes encoded in reveromycin gene cluster from Streptomyces reveromyceticus. Based on biochemical analyses of the enzymes, we demonstrated novel biosynthetic mechanisms responsible for the diversification of polyketide compounds.

Free Research Field

応用微生物学