Analysis of immunomodulatory function of probiotics and its enhancement with food factors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24380065
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: The University of Tokyo
• Principal Investigator: TOTSUKA Mamoru 東京大学, 農学生命科学研究科, 准教授 (70227601)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 乳酸菌 / 制御性Ｔ細胞 / IgA抗体 / フィトケミカル / カルノシン / 制御性B細胞 / 経口免疫寛容

Outline of Final Research Achievements

Immunomodulatory function of probiotics and its enhancement with food factors were investigated. When carnosine, a dipeptide contained abundantly in meat and fish meat, was orally administered to mice, intestinal IgA production was enhanced only in the presence of gut microbiota. Oral administration of live Lactococcus lactis C59 cells enhanced the induction of oral tolerance. The enhancing effect was up-regulated when narigenin, a flavonoid with a regulatory T cell enhancing activity, was orally administered with the probiotic C59. In vitro analyses using murine lymphocytes newly identified flavonoids which enhance the differentiation and/or activity of regulatory T cells or regulatory B cells.

Free Research Field

食品免疫学・食品機能科学