2014 Fiscal Year Final Research Report
Effect of dietary beta-glucan on the resistibility of intestinal epithelia to intestinal viruses and its mechanisms
| Project/Area Number |
24380069
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Kenzi (90391888)
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| Co-Investigator(Renkei-kenkyūsha) |
KATAYAMA Kazuhiko (60342903)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | βグルカン / 腸上皮細胞 / マクロファージ / 腸管ウイルス / 食物繊維 |
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| Outline of Final Research Achievements |
β-Glucan is a polysaccharide contained as a cell wall component of plant, algae, fungi, yeast, etc. It is a glucose-polymer classified into a dietary fiber because of its indigestibility. Possible absorption of dietary β-glucan and activation of intestinal immune system by the absorbed β-glucan were investigated using cell culture systems mimicking intestinal epithelia and viruses as well as virus-like particles (VLPs). β-Glucan taken up by phagocytes was degraded and released, and the released β-glucan activated neighboring cells, resulting in the release of various humoral factors. The β-glucan taken up and degraded by phagocytes was suggested to affect the resistibility of intestinal epithelia to intestinal viruses.
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| Free Research Field |
食品科学
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