Validation for adequacy of serum biomarker in rat population

2014 Fiscal Year Final Research Report

• Project/Area Number: 24380071
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Kyushu University
• Principal Investigator: SATO Masao 九州大学, (連合)農学研究科(研究院), 准教授 (90294909)
• Co-Investigator(Kenkyū-buntansha): SHIROUTI Bungo 九州大学, 大学院農学研究院, 助教 (00548018)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脂肪酸 / 酸化コレステロール / バイオマーカ / 連鎖解析

Outline of Final Research Achievements

In this study, EXHC rats mated with BN rats. In the generation 2, F2, serum dihomo-g-linoeinic acid and DHA levels linked to body weight gain. However, the dihomo-g-linoeinic acid levels did not relate to a gene mutation by linkage analysis. The DHA levels related to a mutation in a gene. Therefore, serum fatty said composition as a biomarker in a population may divide into two groups of life style-lelated and mutation related fatty acids.

Free Research Field

栄養化学