Molecular immunoregulations in the intestinal inflammatory cell intranet by immunobiotics for their advanced application

2015 Fiscal Year Final Research Report

• Project/Area Number: 24380146
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Tohoku University
• Principal Investigator: Kitazawa Haruki 東北大学, (連合)農学研究科(研究院), 准教授 (10204885)
• Co-Investigator(Kenkyū-buntansha): SAITO TADAO 東北大学, 大学院農学研究科, 教授 (00118358) ; ASO HISASHI 東北大学, 大学院農学研究科, 教授 (50241625)
• Co-Investigator(Renkei-kenkyūsha): SUDA YOSHIHITO 宮城大学, 食産業学部, 教授 (90404847)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 畜産学 / 免疫学 / プロバイオティクス / イムノバオティクス / 微生物 / 食品 / 飼料 / 動物

Outline of Final Research Achievements

In this study, detailed mechanisms for the recognition and anti-inflammation of immunobiotics in the gut was analyzed by using livestock intestinal epithelial and dendritic cells. As a result, high recognition for immunobiotics by porcine dendritic cells was observed and a common intracellular regulator induced by immunobiotics was found in porcine intestinal epitheliocytes. Furthermore, anti-inflammatory ability of immunobiotics could be verified in vivo study. This study contributes to progress an understanding the molecular regulation of inflammatory cell intranet by immunobiotics.

Free Research Field

農学