2015 Fiscal Year Final Research Report
Identification of energy sensors mediating suppression of reproductive functions under malnutrition
| Project/Area Number |
24380157
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
美辺 詩織
松田 二子
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 上位細胞 / 栄養 / 繁殖 |
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| Outline of Final Research Achievements |
In lactating cows, gonadal functions are suppressed because of the malnutrition caused by a big milk yield. The suppression is probably due to a decrease in energy levels. Hindbrain ependymocyte is a candidate for energy sensor involved in the suppression of gonadal activities through suppressing gonadotropin secretion in rats. We aimed to get evidence for ependymocytes to sense glucose levels through AMP kinase which is considered to be a energy-sensing molecule in various kinds of cells. In addition, a neural pathway relaying information on the energy level from ependymocytes to the hypothalamic neurons controlling reproduction. As a result, ependymocytes senses extracellular glucose levels through an AMP kinase-mediated mechanism. In addition, the information on energy level might be transmitted from ependymocytes to neurons located in the hypothalamic paraventricular nucleus. The present result would contribute to treatments of reproductive disorders in lactating cows.
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| Free Research Field |
生殖内分泌学
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