Immune responses at the feto-maternal interface : Analysis using artificial tissues including placenta-specific factors

2015 Fiscal Year Final Research Report

• Project/Area Number: 24380159
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Yamaguchi University
• Principal Investigator: Kiso Yasuo 山口大学, 共同獣医学部, 教授 (10142374)
• Co-Investigator(Kenkyū-buntansha): Kusakabe Takeshi 山口大学, 共同獣医学部, 准教授 (20319536)
• Co-Investigator(Renkei-kenkyūsha): Kano Kiyoshi 山口大学, 共同獣医学部, 准教授 (40312516)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 胎盤 / 栄養膜 / 胎盤成長因子 / 血管内皮成長因子 / 血管新生 / アポトーシス / オートファジー / 脱落膜

Outline of Final Research Achievements

To understand immune responses at the feto-maternal interface during pregnancy, we analyzed relationships among immunocompetent cells, placenta-specific factors and cytokine networks using various mouse models. Tumor suppressor factors, autophagy-related factors, abortion-induced factors, diabetes-induced factors, blood pressure regulation factors and obesity-related factors tested in this study can affect kinetics of the placental growth factor and vascular endothelial growth factor, and as a result, their changes can induce abortion or intrauterine growth restriction.

Free Research Field

生殖免疫学