2014 Fiscal Year Final Research Report
Analysis of factors of CDV to expand the host range and its control
| Project/Area Number |
24380166
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MAEDA Ken 山口大学, 獣医学部, 教授 (90284273)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOJIMA Masayuki 国立感染症研究所, ウイルス第一部, 室長 (10422411)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | イヌジステンパーウイルス / 野生動物 / ワクチン / 疫学調査 / レセプター |
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| Outline of Final Research Achievements |
In this project, epidemiological studies on canine distemper virus (CDV), studies on its pathogenicity and studies on effect of vaccine on large animals were carried out. 1) CDV infection among domestic dogs in Vietnam, wild animals in Kochi and Wakayama and domestic dogs in Japan were analyzed. 2) Efficacy and safety of vaccine for dogs on tigers and lions were evaluated. 3) It was proved that feline SLAM and humane C-type lectins, DC-SIGN and DC-SIGNR, functioned as receptors for CDV. 4) ELISA to detect antibody to CDV in all mammalian species was developed. 5) Method for evaluation of pathogenicity of CDV was established.
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| Free Research Field |
獣医微生物学
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