A newly-found 'regulatory antibody': its immunosuppressive mechanisms and prevention of proinflammatory disorders

2014 Fiscal Year Final Research Report

• Project/Area Number: 24380187
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied molecular and cellular biology
• Research Institution: Hiroshima University
• Principal Investigator: KAWAMOTO Seiji 広島大学, 先端物質科学研究科, 教授 (90294537)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 免疫抑制抗体 / 免疫難病制御

Outline of Final Research Achievements

Objective of this study is: 1) to elucidate molecular mechanisms underlying immunosuppressive activity of the newly-found 'regulatory antibody', which shows antigen specificity against nuclear histone H1; and 2) to apply this regulatory antibody to treat proinflammatory disorders.
First, we identified T cell surface cross-reactive antigens, which enabled anti-histone H1 antibody to fulfill its T cell regulatory activity. We also found that the anti-histone H1 antibody not only suppressed type I allergy by acting on mast cells, but also prevented the development of sepsis-like lung injury in mice. These results suggest the effectiveness of anti-histone H1 regulatory antibody against various proinflammatory disorders.

Free Research Field

免疫学・動物細胞工学