Development of aerobic alcohol oxidation systems based on nitroxyl radical-Cu catalysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390001
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: IWABUCHI Yoshiharu 東北大学, 薬学研究科(研究院), 教授 (20211766)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 空気酸化 / アルコール酸化 / 酸化触媒 / 銅ニトロキシド / 不斉酸化 / 化学選択性

Outline of Final Research Achievements

We have successfully developed the highly chemoslective aerobic alcohol oxidation using nitroxyl radical-copper catalysis that realize an efficient transformation of an unprotected amino-alcohol into the corresponding amino-carabonyl compound. We have identified the optimum combination of nitroxyl radical, copper salt, and solution concentration dependent on the type of substrate. Useful information of the catalyst structure-enantioselectivity relationship has been obtained, which will lead the development of an enantioselective aerobic oxidation system.

Free Research Field

化学系薬学