2016 Fiscal Year Final Research Report
Chirality control of catalytic sp3 C-H functionalizations
| Project/Area Number |
24390002
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kanai Motomu 東京大学, 薬学研究科(研究院), 教授 (20243264)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Keywords | 触媒 / 炭素－水素結合活性化 / 不斉反応 / 分子変換 / 医薬化学 |
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| Outline of Final Research Achievements |
The aim of this research is developing catalytic sp3 C-H functionalization reactions that can be extended to asymmetric variants. We developed the first example of catalytic aerobic oxidative and asymmetric coupling reactions between amines and carbon nucleophiles. The combined catalysis of chiral copper complex and N-oxyl radical was useful for this conversion. Based on the results, we developed sp3 C-H alkoxylation, amidation, acetoxylation, and oxygenation reactions.
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| Free Research Field |
有機合成化学
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