Novel reactions and total syntheses of natural products based on cumulated double bonds

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390003
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: MUKAI Chisato 金沢大学, その他部局等, 教授(理事・副学長) (70143914)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アレン / 天然物合成 / 1,3-双極子環化反応 / Pauson-Khand型反応 / ロジウム / モリブデン

Outline of Final Research Achievements

The following six results based on allene chemistry were observed.
1)Regioselective intramolecular [3+2] annulation of allene-nitrones, 2)Molybdenum-mediated intramolecular double Pauson-Khand type reaction of bis(allenyne), 3)Asymmetric total synthesis of (+)-kopsihainanine A, 4)First total synthesis of (+)-indicanone, 5)The synthesis of a carbon analogue of scytonemin based on the double Pauson-Khand type adduct, 6)Syntheses of 6-8-5 tricyclic ring systems by carbonylative [2+2+1] cycloaddition of bis(allene)s

Free Research Field

有機合成化学