2014 Fiscal Year Final Research Report
Development of New Chemoselective Catalyst and its Application to Green Synthetic Process
| Project/Area Number |
24390004
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
OHSHIMA Takashi 九州大学, 薬学研究科(研究院), 教授 (10313123)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 触媒 / 化学選択性 / 環境調和 / 有機合成 |
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| Outline of Final Research Achievements |
In order to realize protecting group-free environmentally friendly synthetic processes, we developed the following catalytic systems, which can reverse innate reactivity of functional groups in a catalytic manner.
(1) chemoselective acylation reactions of alcohol over amine catalyzed by zinc, cobalt, or iron catalyst, (2) chemoselective conjugate addition of alcohol over amine catalyzed by cupper catalyst, and (3) chemoselective and enantioselective alkynylation of ketimine over aldehyde and aldimine.
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| Free Research Field |
有機化学
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