Insulin-containing nanocapsules: an approach to artificial pacreas

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390006
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: ANZAI Jun-ichi 東北大学, 薬学研究科(研究院), 教授 (40159520)
• Co-Investigator(Kenkyū-buntansha): SATO Katsuhiko 東北大学, 大学院薬学研究科, 助教 (80400266)
• Co-Investigator(Renkei-kenkyūsha): EGAWA Yuya 城西大学, 薬学部, 准教授 (90400267)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 交互累積膜

Outline of Final Research Achievements

Phenylboronic acid-modified polymers and insulin-containing carcium carbonate particles (spherical particles of 5-10 nm in diameter) were prepared. The release of insulin from the particles could be regulated by coating layer-by-layer films on the particles. Phenylboronic acid-modified poly(allylamine) and dendrimers were found to be useful for constructing insulin-delivery systems. It was also found that layer-by-layer films combined with enzyme can be disintegrated in the presence of glucose. The results show that phenylboronic acid-modified thin film are useful materials for developing insulin delivery systems.

Free Research Field

機能薄膜