2015 Fiscal Year Final Research Report
Regulation of nerural circuit formation by prostaglandins
| Project/Area Number |
24390017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SEGI Eri (NISHIDA Eri) 東京理科大学, 基礎工学部, 准教授 (70378628)
FURUYASHIKI Tomoyuki 神戸大学, 医学研究科, 教授 (20362478)
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| Research Collaborator |
HOHJOH Hirofumi
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 視床下部 / 海馬 / 性分化 / 性行動 / プロスタノイド / 神経回路 / フェロモン / 細胞骨格 |
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| Outline of Final Research Achievements |
In this study, we found that prostaglandin (PG) E2 stimulates sex-specific neural circuit formation by regulating cytoskeleton in preoptic neurons. Moreover, we revealed in zebrafish that PGF2alpha activates selective neural circuit and induces male reproductive behavior by acting on particular type of olfactory receptors.
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| Free Research Field |
生化学・分子生物学
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