2014 Fiscal Year Final Research Report
Single calcium channel(s) formed by Abeta oligomer(s)
| Project/Area Number |
24390020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SAIDO Takaomi 独立行政法人理化学研究所, 脳科学総合研究センター, シニア・チームリーダー (80205690)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | アルツハイマー病 / アミロイドβペプチド / オリゴマー / カルシウムチャネル |
|---|
| Outline of Final Research Achievements |
We showed the possibility that Aβ43, an essential molecule for pathological process of Alzheimer’s disease, could induce channel activity. Also, we successfully prepared Aβ oligomers by PICUP (photo-induced cross-linking of unmodified proteins) method and established the purification procedure with HPLC.
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| Free Research Field |
医歯薬学
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