2015 Fiscal Year Final Research Report
Regulation of vascular endothelial cell functions and exhibition of heavy metal toxicity through zinc transporter expression
| Project/Area Number |
24390034
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Chika 東邦大学, 薬学部, 教授 (70230571)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 金属輸送体 / 血管内皮細胞 / 亜鉛 / カドミウム / 細胞毒性 |
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| Outline of Final Research Achievements |
Vascular endothelial cells are the only cell type that directly contact with blood. It was reported that organ toxicity of cadmium possibly depends on the toxicity of the metal to vascular endothelial cells; however, the mechanisms have been unclear. In the present study, we found that TGF-β, an inflammatory cytokine that can influence the cytotoxicity of cadmium to vascular endothelial cells, induces the expression of a zinc transporter ZIP8 in vascular endothelial cells. In addition, it was revealed that the expression level of ZIP8 as well as metallothionein induction is important for interaction of zinc with cadmium in the cells.
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| Free Research Field |
環境健康学，毒性学，バイオオルガノメタリクス
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