Mechanism to generate lipid-based supramolecular structures

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390045
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Nagoya University
• Principal Investigator: FUJIMOTO Toyoshi 名古屋大学, 医学(系)研究科(研究院), 教授 (50115929)
• Co-Investigator(Kenkyū-buntansha): OHSAKI Yuki 名古屋大学, 大学院医学系研究科, 講師 (00378027) ; SUZUKI Michitaka 名古屋大学, 大学院医学系研究科, 特任助教 (80456649)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脂質ドメイン / 脂肪滴 / オートファゴソーム / 電子顕微鏡

Outline of Final Research Achievements

We studied on lipid-based supramolecular structures, i.e., lipid droplet, autophagosome, and lipid domain. The results obtained are as follows: 1) In mice lacking a lipid droplet-resident protein, UBXD8, in liver, hepatocytes are deficient in lipoprotein secretion and exhibit an atypical type of steatosis; 2) Phosphatidylinositol 3-phosphate, a phospholipid indispensable for autophagy, takes drastically different distributions in autophagosomes between budding yeast and mammalian cells; 3) Distribution of phosphatidylcholine across the plasmalemmal lipid bilayer is different between budding yeast and mammalian cells.

Free Research Field

細胞生物学