Physiological and Pathological Function of Cellular Stress Responses

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390049
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Gunma University
• Principal Investigator: IWAWAKI Takao 群馬大学, 先端科学研究指導者育成ユニット, 講師 (50342754)
• Research Collaborator: OIKAWA Daisuke 群馬大学, 生体調節研究所, 助教 ; TAKAHASHI Yayoi 群馬大学, 先端科学研究指導者育成ユニット, 研究支援者 ; ASAI Chiaki 群馬大学, 先端科学研究指導者育成ユニット, 研究支援者 ; YOSHINO Mayuko 群馬大学, 先端科学研究指導者育成ユニット, 研究支援者
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 小胞体ストレス / 酸化ストレス / タンパク質品質管理 / 脂質代謝 / 炎症 / ガン

Outline of Final Research Achievements

Since 2012, I have focused on visualization of cellular stress in vivo and functional analysis of IRE1 molecule and other ER stress responsive molecules. In the former research, we developed a transgenic mouse model for monitoring oxidative stress, and visualized oxidative stress with cerebral ischemia and maralia infection using the transgenic mice. In the latter research, we indicated that IRE1 and/or XBP1 contributes to function of dendritic cells, differentiation of B cells, lipid metabolism, acetaminophen metabolism, placental angiogenesis, suppression of intestinal tumorigenesis, and some functions of goblet cells and Paneth cells in guts.

Free Research Field

分子細胞生物学