2014 Fiscal Year Final Research Report
Molecular mechanisms underlying formation of lymphatic tissue microenvironment required for preventing autoimmunity
| Project/Area Number |
24390071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Jun-ichiro 東京大学, 医科学研究所, 教授 (70176428)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 自己免疫 / 胸腺 / 制御性T細胞 / 抗原提示細胞 / 癌免疫 |
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| Outline of Final Research Achievements |
Autoimmune diseases are provoked when acquired immune response to self-tissue-derived antigens initiate and continue. Normally, several different mechanisms prevent onsets of autoimmune diseases. Regulatory T cells suppress or attenuate immune responses and thereby play a critical role in preventing autoimmune disease onsets. A large part of regulatory T cells are generated in lymphoid organ thymus. This study identified a molecular mechanisms regulating formation of microenvironment required for generation of regulatory T cells in the thymus. Moreover, involvements of such mechanism in regulation of immune responses to self-tissues and tumors were addressed. This information would provide important insights in medical application of regulator T cells in future.
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| Free Research Field |
分子免疫学
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