2016 Fiscal Year Final Research Report
Functional analysis of newly identified inducible regulatory T cells in immunological reaction and tolerance
| Project/Area Number |
24390073
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | University of Fukui (2014-2016)
Kyoto University (2012-2013) |
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Principal Investigator |
Sugai Manabu 福井大学, 学術研究院医学系部門, 教授 (90303891)
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| Co-Investigator(Kenkyū-buntansha) |
黒岡 尚徳 福井大学, 医学部, 准教授 (00293879)
森 健太郎 福井大学, 医学部, 助教 (50397296)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Keywords | 慢性炎症 / 自己免疫疾患 / 腫瘍免疫 |
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| Outline of Final Research Achievements |
Cell fate determination of CD4 T cells (helper T cells) or CD8 T cells (cytotoxic T cells) is occurred in the thymus in a mutually exclusive manner. We found that CD4 T cells differentiate into CD8aa T cells in the periphery in response to transforming growth factor-beta1(TGF-beta1), retinoic acids (RA) and Interleukin-2(IL-2). These cells were designated as CD4-derived CD8aa T cells. We further examined the immuno-regulatory role of CD4-derived CD8aaT cells in various autoimmune models.
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| Free Research Field |
分子生物学
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