Contribution of megakaryocytes and platelets to pathogenesis of chronic inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390075
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: MOTOHASHI Hozumi 東北大学, 加齢医学研究所, 教授 (00282351)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 転写因子 / 血小板 / 巨核球 / 炎症 / ストレス

Outline of Final Research Achievements

A goal of this research was to clarify a role of platelets and megakaryocytes during the pathogenesis of chronic inflammation through examining the function of NF-E2 p45 in proliferation and differentiation of megakaryocytes and platelet production. We clarified a profile of NF-E2 p45 target genes in megakaryocytes and found that NF-E2 p45 not only promotes platelet production but also confers sufficient reactivity on platelets. It is plausible that these NF-E2 target genes are upregulated during inflammation and contribute to the pathogenesis.

Free Research Field

転写因子による遺伝子発現制御機構とその生体内機能の解明