Comprehensive identification of new diagnostic and therapeutic targets of the esophago-gastric cancer to overcome therapy-resistant cancer stem cell and its clinical application

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390088
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: YASUI WATARU 広島大学, 医歯薬保健学研究院, 教授 (40191118)
• Co-Investigator(Renkei-kenkyūsha): OUE Naohide 広島大学, 大学院医歯薬保健学研究院, 准教授 (60346484) ; KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 胃癌 / 食道癌 / 治療耐性 / 癌幹細胞 / CAST法 / 診断・治療標的

Outline of Final Research Achievements

As candidate diagnostic targets of esophago-gastric cancers associated with therapy-resistant cancer stem cells, TM9SF3, ZDHHC14, FKTN, PCDHB9, BST2, etc. were identified through comprehensive gene expression analysis using CAST method. The functional analysis revealed that they were possible therapeutic targets. Of the cancer stem cell markers of gastric cancer, ALDH1 was pointed out the possibility to play a role in metastasis of undifferentiated type gastric cancer. These findings will contribute to the application to the diagnosis and treatment for therapy-resistant cancer having tumor heterogeneity.

Free Research Field

医歯薬学