Role of NKG2D ligands in immunological surveillance and disease pathogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390091
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: KASAHARA Masanori 北海道大学, 医学(系)研究科(研究院), 教授 (30241318)
• Co-Investigator(Kenkyū-buntansha): OTSUKA Noriyuki 北海道大学, 大学院医学研究科, 助教 (00447046) ; MIYATAKE Yukiko 北海道大学, 大学院医学研究科, 助教 (10421984)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: NKレセプター / DETC / NKG2D

Outline of Final Research Achievements

NKG2D ligands are a group of major histocompatibility complex class I-like molecules whose expression is induced by cellular stresses such as transformation and viral infections. They act as a danger signal alerting the immune system to the presence of abnormal cells. In this project, we analyzed the function of H60c, a mouse NKG2D ligand assumed to be involved in the immune surveillance and maintenance of homeostasis at body surfaces. We also analyzed the expression of NKG2D ligands in human cancer.

Free Research Field

病理学