Elucidation of brain protective mechanisms by low molecular endogenous substances with neuroprotective and neuroregenerative effects

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390139
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Kyoto University
• Principal Investigator: Akaike Akinori 京都大学, 薬学研究科(研究院), 教授 (80135558)
• Co-Investigator(Kenkyū-buntansha): KUME Toshiaki 京都大学, 大学院薬学研究科, 准教授 (10303843) ; IZUMI Yasuhiko 京都大学, 大学院薬学研究科, 助教 (60456837)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 薬理学 / 神経保護 / セロフェンド酸

Outline of Final Research Achievements

Serofendic acid protected cardiac myocytes against myocardial ischemia-reperfusion injury by preserving the functional integrity of mitochondria. Neuroprotective effect of donepezil was involved in the modulation of the activity of GSK-3β. Donepezil prevented okadaic acid-induced neuronal death by the inhibition of the phosphorylation of Tau. Aβ-mediated toxicity is caused by the turn that favors toxic oligomers, which increase generation of ROS.

Free Research Field

薬理学