Area-specific human and parasite polymorphism in the context of global malaria eradication.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390141
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Osaka City University
• Principal Investigator: KANEKO AKIRA 大阪市立大学, 医学(系)研究科(研究院), 教授 (60169563)
• Co-Investigator(Kenkyū-buntansha): TERAMOTO Isao (KIMATA Isao) 大阪市立大学, 医学(系)研究科(研究院), 講師 (20153174) ; ISOZUMI Rie 大阪市立大学, 医学(系)研究科(研究院), 講師 (30550355) ; HIRATSUKA Masahiro 東北大学, 薬学研究科(研究院), 准教授 (50282140)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: マラリア撲滅 / 熱帯熱マラリア / アルテミシニン / G6PD欠損症 / 原虫薬剤耐性 / ケニア / オセアニア

Outline of Final Research Achievements

We conducted surveillance for mutations in the Plasmodium falciparum K13-propeller gene of an artemisinin-resistant candidate on 4 islands and one coastal village in Lake Victoria, Kenya with high transmission in 2012-2013. Four new types of nonsynonymous and five new types of synonymous mutations were detected among the 539 samples analyzed. All the mutations found were different from those reported in Cambodia and no mutations were observed at more than two of these five different sites. Furthermore, only one type of mutation, A578S, from the Mfangano Island was detected during two different seasons, whereas other mutations were not observed in the next season half a year later. Monitoring these molecular markers and the efficacy of antimalarial drugs is critical for increasing our understanding of artemisinin resistance and predicting their spread.

Free Research Field

マラリア撲滅研究