Molecular epidemiological study on oxidative stress and type 2 diabetes mellitus in a population-based cohort

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390166
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyushu University
• Principal Investigator: OHNAKA KEIZO 九州大学, 医学(系)研究科(研究院), 講師 (30325518)
• Co-Investigator(Kenkyū-buntansha): TAKAYANAGI Ryoichi 九州大学, 大学院医学研究院, 教授 (30154917) ; YAMAMOTO Ken 九州大学, 生体防御医学研究所, 准教授 (60274528) ; KONO Suminori 九州大学, 大学院医学研究院, 教授 (70128015)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: oxidative stress / type 2 diabetes mellitus / population-based cohort / molecular epidemiology

Outline of Final Research Achievements

We prospectively investigated the association between type 2 diabetes mellitus (T2DM) and gene polymorphisms related with oxidative stress, such as bilirubin-metabolizing enzymes or anti-oxidative enzymes, in a community-based cohort study. No significant association was observed between the incidence of T2DM and serum bilirubin or single nucleotide polymorphisms (SNPs) of UGT1A1, HMOX1, but one SNP examined among the genes of anti-oxidative enzymes was associated with the incidence of T2DM. Several SNPs reported in previous genome-wide association studies (GWAS) have also significant association with the incidence of T2DM in this cohort study. Intake of rice was positively related with the incidence of T2DM, while consumption of green tea was related negatively, especially in women. Intake of green tea reported to have anti-oxidative effect may be protective for the increased risk of T2DM with higher intake of rice.

Free Research Field

Epidemiology