Role of disturbance of immune response in alcohol-related death

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390175
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Osaka University (2013-2014); Sapporo Medical University (2012)
• Principal Investigator: MATSUMOTO HIROSHI 大阪大学, 医学(系)研究科(研究院), 教授 (60263092)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Kana 大阪大学, 大学院医学系研究科, 助教 (00581034)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アルコール関連死 / 突然死 / 大腿骨頭壊死 / 自然免疫 / 免疫撹乱 / TLR4 / TLR7 / TLR９

Outline of Final Research Achievements

We hypothesized that alcohol-related death can be caused by disturbance of immune system. We performed a variety of model rats such as a sudden death model, brain contusion model, ostemonecrosis of femoral head, hyperthermia and so on. In all the model rats, we confirmed the disturbance of immune system, especially innate immune system via TLR4, TLR7, or TLR9. In femoral head osteonecrosis model, we found TRIM21 can be strongly related to promote the pathogenesis.

Free Research Field

アルコール医学　死因究明学