Elucidation of spiral interactions of virus and inflammation in hepatitis C-associated hepatocarcinogenesis as revealed by microRNA analysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390183
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: KOIKE KAZUHIKO 東京大学, 医学部附属病院, 教授 (80240703)
• Co-Investigator(Kenkyū-buntansha): MORIYA Kyoji 東京大学, 医学部附属病院, 教授 (00272550)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肝癌 / 肝炎ウイルス / 炎症

Outline of Final Research Achievements

To determine the roles of viral proteins and inflammation in hepatocarcinogenesis, the HCV core gene transgenic mice were mated with ①liver-specific AID-KO mice, and ②liver-specific activation-induced cytidine deaminase (AID) Tg mice. In HCV-Tg/AID-/- mice, the incidence of HCC was not different from that in HCV-Tg/AID+/+ mice, showing that AID does not play a central role in HCV-associated hepatocarcinogenesis. On the other hand, in HCV-Tg/AID+++/+++ mice, 90% of those mice developed HCC, showing a synergy of inflammation-induced genetic aberrations and the viral oncoprotein in hepatocarcinogenesis.

Free Research Field

消化器病学