2014 Fiscal Year Final Research Report
High throughput screening of chemical library for antiviral compounds for hepatitis viruses
Project/Area Number |
24390185
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Hokkaido University |
Principal Investigator |
SAKAMOTO Naoya 北海道大学, 医学(系)研究科(研究院), 教授 (10334418)
|
Co-Investigator(Kenkyū-buntansha) |
ASAHINA Yasuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座教員 (00422692)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 肝炎ウイルス |
Outline of Final Research Achievements |
We have conducted a high throughput screening of chemical library for antiviral compounds against hepatitis C and hepatitis B viruses and acquired the following results. 1. GPx8, a host protein, was cleaved by HCV-NS3/4A serene protease and enhanced viral replication in the host cells. 2. L-carnitine suppressed HCV viral assembly by targeting formation of cellular lipid vesicles. With the above results, it is possible that we can constitute novel antiviral therapeutics against hepatitis viruses.
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Free Research Field |
消化器内科学
|