2014 Fiscal Year Final Research Report
Identification of Symbiosis pattern decision factors and its reeducation program
| Project/Area Number |
24390190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | プロバイオティクス / 腸内細菌 / 炎症性腸疾患 / ディスバイオーシス |
|---|
| Outline of Final Research Achievements |
In the first project, a probiotic strain, Clostridium butyricum (CB), induced FOXP3+ regulatory T cells (iTreg) in the colon of normal mice. Although CB suppressed the development of acute DSS colitis, CB did not induce iTreg, but did IL-10-producing macrophages. The preventive effect of CB was not observed in DSS-administered macrophage-specific IL-10 KO mice. In addition, CB-monoassociated mice did not develop DSS colitis (Cell Host & Microbe 2013).
In the second project, surprisingly, mice treated with vancomycin and biotin-deficient diet suffered from broad alopecia on the back with dysbiosis composed of a specific lactobacillus strain that reached to 60% dominancy. Also, these mice produced a large amount of a specific amines that seemed to be the key metabolites to induce alopecia.
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| Free Research Field |
炎症性腸疾患
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