The development of novel tools for the diagnosis, prevention, and treatment of cardiovascular diseases based on Cyclophilin A

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390193
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Co-Investigator(Kenkyū-buntansha): 高橋 潤 東北大学, 大学病院, 講師 (00375081) ; 福本 義弘 久留米大学, 医学部, 教授 (70363372)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 心血管疾患 / 動脈硬化 / 肺高血圧症 / バイオマーカー / 臨床応用研究 / トランスレーショナルリサーチ

Outline of Final Research Achievements

Based on this research funding, we demonstrated that plasma CyPA levels are increased in patients with coronary artery disease (CAD). Plasma CyPA levels were significantly higher in patients with coronary stenosis compared to those without it. A positive correlation was noted between plasma CyPA levels and significant coronary stenosis. The average number of stenotic coronary arteries and the need for coronary intervention were significantly increased in the quartiles of higher CyPA levels. Furthermore, plasma levels of CyPA significantly reduced after medical treatment of risk factors. Importantly, plasma CyPA levels predicted all-cause death, rehospitalization and coronary revascularization in CAD patients and that combination with other biomarkers (hsCRP, BNP) further enhanced the prognostic impacts of CyPA in those patients. During the 3 years funding period, we had 42 presentations in international conferences and published 36 original papers.

Free Research Field

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