Molecular regulation of cardiac function by the automatic nervous system

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390200
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yokohama City University
• Principal Investigator: ISHIKAWA Yoshihiro 横浜市立大学, 医学(系)研究科(研究院), 教授 (40305470)
• Co-Investigator(Kenkyū-buntansha): UMEMURA Masanari 横浜市立大学, 医学部, 助教 (50595353)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 交感神経 / セカンドメッセンジャー / 心臓 / 機能制御

Outline of Final Research Achievements

Adenylyl cyclase is a target enzyme of catecholamine signal, which produces cAMP in the cell. This second messenger classically is known to activate protein kinase A, which is known as cAMP-dependent kinase. Recently, however, a second target enzyme, known as “Epac”, has been widely recognized. This enzyme is distinct from the classic PKA and is known to regulate the activity of various small G proteins. In thus study, we compared the role of Epac with that of PKA, in order to understand the cAMP signal network. We particularly carefully examined it from the stand point of the regulation of cardiac function and the development of pathophysiology. This study, accordingly, successfully prevailed new mechanisms of cAMP signaling in the heart.

Free Research Field

循環制御医学