2014 Fiscal Year Final Research Report
Elucidation of mineralocorticoid receptor/ glucocorticoid receptor paradox and its application to kidney disease therapy
| Project/Area Number |
24390214
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Juntendo University (2013-2014)
The University of Tokyo (2012) |
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Principal Investigator |
NAGASE Miki 順天堂大学, 医学(系)研究科(研究院), 准教授 (60302733)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 鉱質コルチコイド受容体 / 糖質コルチコイド受容体 / Rac1 / 足細胞 / 蛋白尿 / メタボリックシンドローム / マクロファージ / 心筋細胞 |
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| Outline of Final Research Achievements |
In the present study, we examined the mechanisms of Rac1-MR signaling in target organ injury in rodents. Podocyte-specific Rac1 activation mice as well as Rac1 KO mice spontaneously developed podocyte injury, albuminuria, and glomerulosclerosis. Rac1 activity was correlated with MR activity and organ protective response of MR antagonist. Myeloid-specific and cardiomyocyte-specific Rac1/MR KO mice were protected against renal and cardiac injury. Activation of Rac1/MR was demonstrated in obese diabetic KKAy mice, TAC-induced cardiac injury, AngII/salt-induced renal injury, and senescence-associated skin injury models.
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| Free Research Field |
腎臓病学、解剖学、内科学
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