2015 Fiscal Year Final Research Report
Exploring rare variants associated with pediatric asthma for personalized medicine by exome analysis
| Project/Area Number |
24390251
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Noguchi Emiko 筑波大学, 医学医療系, 教授 (40344882)
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| Co-Investigator(Kenkyū-buntansha) |
Okamura Koji 国立成育医療研究センター, システム発生再生医学研究部, 室長 (80456194)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | エクソーム / アレルギー |
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| Outline of Final Research Achievements |
The aim of this study is to investigate rare variants associated with asthma by exome analysis using next generation sequencer. We performed exome analyses on 67 patients who were diagnosed with asthma. Control genotype/allele frequencies were obtained from Human Genetic Variation Database. In the genomic regions which were identified to be associated with asthma by genome-wide association studies, we found two missense variants (one in IL1RL1 and the other in GSDMB) to be possibly associated with asthma (P < 0.05). We also found several candidate rare variants to be associated with asthma.
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| Free Research Field |
遺伝医学 アレルギー学
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